The Il1 Gene Cluster Is a Major Locus Determining Susceptibility to Ankylosing Spondylitis
نویسندگان
چکیده
A.E. Timms1, A.M. Crane1, A.-.M. Sims1, H. Cordell2, L. Bradbury1, O. Beynon1, G.R. Duff5, L.R. Cardon4, A. Calin3, P. Wordsworth1 , M.A. Brown1. 1Institute of Musculoskeletal Sciences, The Botnar Research Centre, Oxford, United Kingdom; 2Cambridge Institute of Medical Research, Addenbrookes Hospital, Cambridge, United Kingdom; 3Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom; 4Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; 5Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
منابع مشابه
نقش تعادل میان KIRهای مهاری و فعال کنندگی در تعیین استعداد ابتلا به اسپوندیلیت انکیلوزان
Background : Ankylosing spondylitis (AS) represents a progressive and debilitating disease that affects approximately 0.9% worldwide. So far the precise mechanisms underlying the initiation and progression of AS is still unclear. Linkage between HLA-B27 and AS remains the strongest association between a human leukocyte antigen (HLA) class I molecule and disease. Despite intensive research, the ...
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Background: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-s...
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Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...
متن کاملSusceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta 1 (TGFB1) gene polymorphisms.
BACKGROUND Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis. Transforming growth factor beta 1 (TGF beta 1) is a multifunctional cytokine that plays a key role in inflammation. Two functional single nucleotide polymorphisms (SNPs) in the TGFB1 gene have been described: TGFB1 T869C and TGFB1 G915C. OBJECTIVE To determine whether these SNPs contribute to a...
متن کاملThe effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis.
OBJECTIVES To determine whether genetic polymorphisms in or near the transforming growth factor beta1 (TGFB1) locus were associated with susceptibility to or severity of ankylosing spondylitis (AS). METHODS Five intragenic single-nucleotide polymorphisms (SNP) and three microsatellite markers flanking the TGFB1 locus were genotyped. Seven hundred and sixty-two individuals from 184 multiplex f...
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